1. Sox2 is essential for SLG regeneration following radiation injury
Sox2 is essential for SLG regeneration following radiation injury A–DRepresentative images of control (0 Gy; no IR) and irradiated (10 Gy; IR) SLG from wild‐type (A) and Sox2CreERT2;Rosa26mTmG (D) mice and analyzed 1, 3, and 14 days later. (A–C) SLG was stained for nerves (TUBB3), SOX2, CyclinD1 (CCND1), and nuclei (A, C), and nerve density calculated (B). (C) The number of SOX2+ and CCND1+ cells was quantified. (D) Sox2CreERT2;Rosa26mTmG mice were traced for 14 days post‐irradiation (IR) and immunostained for SOX2 (D, red). White arrowheads indicate SOX2‐negative progeny. Scale bars in (A and D) are 50 μm.ESox2CreERT2;Sox2fl/fl mice and wild‐type littermates were irradiated with 10 Gy IR and SLG analyzed 13 days later. SLG was immunostained for SOX2, AQP5, and nuclei. Scale bar = 50 μm.Data information: Data in (B) are means + SD, n = 3 with individual values plotted. Data in (C) were calculated from three non‐consecutive fluorescent sections of each SLG from n = 3 mice/treatment, are means + SD, and data were analyzed using a one‐way analysis of variance with post hoc Dunnett's test. SOX2+ (D1) *P = 0.0487, SOX2+CCND1+ (D3) *P = 0.318, SOX2+CCND1+ (D7) *P = 
Elaine Emmerson et al. EMBO Mol Med. 2018;emmm
© as stated in the article, figure or figure legend