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Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary.

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Presentation on theme: "Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary."— Presentation transcript:

1 Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass  M.S. Avidan, MD, J.H. Levy, MD, H. van Aken, MD, R.O. Feneck, MD, R.D. Latimer, MD, E. Ott, MD, E. Martin, MD, D.E. Birnbaum, MD, L.J. Bonfiglio, BSN, CRNA, D.K. Kajdasz, PhD, G.J. Despotis, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 130, Issue 1, Pages (July 2005) DOI: /j.jtcvs Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 rhATIII activity for patients in each group at 3 time points around the CPB period. Time 0, Before institution of CPB; 30 min on CPB, 30 minutes after institution of CPB; Preprotamine, CPB period just before protamine administration. The normal range for plasma AT activity is 70% to 130%. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Thrombin-antithrombin complex concentrations for patients in each group at 3 time points around the CPB period. Time 0, Before institution of CPB; 30 min on CPB, 30 minutes after institution of CPB, Preprotamine, CPB period just before protamine administration. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Activated clotting times for patients in each group over the course of the study before and during CPB. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions


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