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Elevated non-esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence 

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Presentation on theme: "Elevated non-esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence "— Presentation transcript:

1 Elevated non-esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence  Sara D.M. Valckx, M.Sc., Veerle Van Hoeck, Ph.D., Maria Arias-Alvarez, Ph.D., Veronica Maillo, M.Sc., Angela P. Lopez-Cardona, M.Sc., Alfonso Gutierrez-Adan, Ph.D., Mario Berth, Ph.D., Rita Cortvrindt, M.Sc., Peter E.J. Bols, Ph.D., Jo L.M.R. Leroy, Ph.D.  Fertility and Sterility  Volume 102, Issue 6, Pages e1 (December 2014) DOI: /j.fertnstert Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Follicle steroidogenesis. Estradiol and P concentrations in the culture medium of day-12 and day-13 follicles cultured in basal NEFA, high SA, high OA, or high NEFA conditions. Absolute E2 reduction and P rise between day 12 and day 13 are also shown. Data are presented as mean ± SD. a,b Different superscripts on a bar indicate a statistically significant difference between treatments (P<.05). Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Granulosa cell gene expression patterns. Comparison of relative transcript abundance in murine day-13 granulosa cells. Follicles were cultured for 12 days in basal NEFA, high SA, high OA, or high NEFA conditions (4 replicates), and granulosa cells were obtained on day 13, at 20 hours after a final maturation stimulus. a,b Different superscripts on a bar indicate a statistically significant difference between treatments (P<.05). Data are presented as relative transcript abundance ± SEM. Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

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