1. Angiogenesis and Angiostatin

2. Angiogenesis
Speculation: the body purposefully denies its cells the ability to induce angiogenesis to prevent huge tumors from growing.
Tumors overcome this defense
“Angiogenic switch”

3. Angiogenesis Inhibitors
Mice with pancreatic tumors
treated with anti-VEGF antibodies
(destroy VEGF, angiogenesis reduced)

4. Angiogenesis Inhibitors
tumor size regressed over 50%!
surviving tumor cells produce elevated levels of fibroblast growth factors
angiogenesis still occurred :(

5. Angiogenesis Inhibitors
Some approved by FDA
used if other treatments did not work, or in addition to other treatments.
Cut off supply of blood, tumor will die!

6. Angiogenesis Inhibitors
Side effects:
problems with wound healing, kidney and heart function, fetal development, reproduction, clots, stroke, heart attack, gastrointestinal perforation, fistulas
birth defects?

7. Angiostatin Produced by primary tumor! keeps metastases at bay
remove the primary tumor, metastases will flourish

8. Angiostatin