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Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs  O Grottke, T Braunschweig, L Zimmermann,

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Presentation on theme: "Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs  O Grottke, T Braunschweig, L Zimmermann,"— Presentation transcript:

1 Recombinant factor VIIa reduces bleeding after blunt liver injury in coagulopathic, hypofibrinogenaemic pigs  O Grottke, T Braunschweig, L Zimmermann, R Kopp, B Lauritzen, M Coburn, R Tolba, R Rossaint  British Journal of Anaesthesia  Volume 105, Issue 6, Pages (December 2010) DOI: /bja/aeq263 Copyright © 2010 The Author(s) Terms and Conditions

2 Fig 1 (a) PT and (b) fibrinogen concentration at baseline, after haemodilution, fibrinogen substitution, and trauma. *P<0.05 vs control; †P<0.05 vs rFVIIa; ‡P<0.05 vs fibrinogen. British Journal of Anaesthesia  , DOI: ( /bja/aeq263) Copyright © 2010 The Author(s) Terms and Conditions

3 Fig 2 Thromboelastometry analysis: (a) CT, (b) CFT, and (c) MCF at baseline (after splenectomy), after haemodilution, after fibrinogen substitution, and at the end of the observation period (trauma). *P<0.05 vs control; †P<0.05 vs rFVIIa; ‡P<0.05 vs fibrinogen. British Journal of Anaesthesia  , DOI: ( /bja/aeq263) Copyright © 2010 The Author(s) Terms and Conditions

4 Fig 3 Plasma concentrations of rFVIIa at various time points after rFVIIa administration after 30 s of injury [mean (sd)]. British Journal of Anaesthesia  , DOI: ( /bja/aeq263) Copyright © 2010 The Author(s) Terms and Conditions

5 Fig 4 Total blood loss at the end of the observation period (ml). *P<0.05 vs control; †P<0.05 vs rFVIIa; ‡P<0.05 vs fibrinogen. British Journal of Anaesthesia  , DOI: ( /bja/aeq263) Copyright © 2010 The Author(s) Terms and Conditions

6 Fig 5 Data of survival are presented as a Kaplan–Meier curve. *P<0.05 vs control. British Journal of Anaesthesia  , DOI: ( /bja/aeq263) Copyright © 2010 The Author(s) Terms and Conditions


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