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Molecular Imaging in Gastrointestinal Disease

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Presentation on theme: "Molecular Imaging in Gastrointestinal Disease"— Presentation transcript:

1 Molecular Imaging in Gastrointestinal Disease
Umar Mahmood, Michael B. Wallace  Gastroenterology  Volume 132, Issue 1, Pages (January 2007) DOI: /j.gastro Copyright © 2007 AGA Institute Terms and Conditions

2 Figure 1 Schematic diagram of probe activation. Fluorochromes are covalently coupled to a polylysine backbone. Because of the proximity of the fluorochromes, autoquenching occurs so that almost no fluorescent signal can be detected in the nonactivated state. After designated enzyme cleavage, fluorochromes are released from the carrier and become brightly fluorescent. Gastroenterology  , 11-14DOI: ( /j.gastro ) Copyright © 2007 AGA Institute Terms and Conditions

3 Figure 2 Frames from a murine colonoscopy demonstrates 2 colonic adenocarcinomas that result in minimal anatomic distortion of the lumen (left), but which are readily apparent on simultaneously acquired false-colored NIR images (right). Gastroenterology  , 11-14DOI: ( /j.gastro ) Copyright © 2007 AGA Institute Terms and Conditions


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