1. Clinical Fellow at Imperial College – how I got here and what Im doing Dr Victoria Salem

2. Outline My career pathway to date Grant application process My PhD research (briefly!) Pros and cons of an academic career Work/life balance (maternity….)

3. Medical School Intercalated BSc Medical Physics 1999 MBBS 2002 Early Clinical Training 2002-2003 House officer posts 2003 -2004 A+E / TRAVEL 2004-2006 SHO Medical Rotation Academic Clinical Fellow 2006 - MRCP ACF/SpR Diabetes and Endocrinology

4. Early SpR years 2006-2007 Watford General Hospital 2007-2008 Northwick Park Hospital GRANT APPLICATION PROCESS 3 months per year in lab Pilot data

5. Grant Application Process ACF – advantage of dedicated lab time – Do I want to be an academic? – Pilot data – Forging a relationship with your supervisors – Preparing for grant applications Research training fellowships – chosing the right one for you KEEP TRYING!

6. Early SpR years 2006-2007 Watford General Hospital 2007-2008 Northwick Park Hospital GRANT APPLICATION PROCESS 3 months per year in lab Pilot data PhD MRC CRTF October 2008 PhD (and 3 babies) Sept 2012

7. My Research Gut hormones and fMRI Potential of anorectic gut hormones to treat obesity CNS mechanism of action in humans?

8. fMRI study protocol

9. Co-administration of PYY and GLP-1 reduces ad libitum energy intake (EI) at lunch ** P<0.05 vs fasted saline *** P<0.0001 vs fasted saline 23% 12% 16% 27%

10. Modulation of BOLD signal by co- administration of PYY and GLP-1 OFC AmygdalaInsula

11. Co-administration of PYY & GLP-1 reduces BOLD signal change in brain food reward regions (amalgamated ROI data) *** P<0.0001 vs. fasted saline # P<0.001 vs. combined Salem V. et al 2011; 14(5): 700-6

12. PhD years Learning to become a scientist Finding a mentor Developing research skills – Statistics, time management, grant writing – Specific to your chosen specialty Keeping abreast of clinical developments – Maintaining practical proficiencies Attending meetings and presenting your own data Publications

13. What next…? The pyramid gets steeper….. Applying for Clinical Lectureship – 50/50 clinical/lab Applying for Postdoctoral Funding – Intermediate Training Fellowships – Smaller project grants – Building up publication record – Consolidating research skills – Finding your niche and networking

14. Pros and Cons of an Academic Career Hugely satisfying – whatever level you reach 2 nd career: Clinician Scientist Cutting edge of your specialty More flexible working hours CCST will be delayed Less certainty Highly competitive Money No shifts

15. Final word - babies 1.TIME MANAGEMENT 2.TEAM WORKING 3.GOOD CHILDCARE