Presentation is loading. Please wait.

Presentation is loading. Please wait.

Reversal of neuromuscular block

Similar presentations


Presentation on theme: "Reversal of neuromuscular block"— Presentation transcript:

1 Reversal of neuromuscular block
A. Srivastava, J.M. Hunter  British Journal of Anaesthesia  Volume 103, Issue 1, Pages (July 2009) DOI: /bja/aep093 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Structure of sugammadex showing eight glucopyranoside units linked together via α 1→4 linkages to maintain a doughnut-like shape. Reproduced with permission.121 British Journal of Anaesthesia  , DOI: ( /bja/aep093) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Structural arrangements of glucopyranose units in a γ-cyclodextrin, showing negatively charged hydroxyl groups at the rims creating the primary and secondary faces. Reproduced with permission.121 British Journal of Anaesthesia  , DOI: ( /bja/aep093) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 The encapsulation process: sugammadex carboxyl groups interact with the steroidal rings A, B, C, and D of the aminosteroid NMBA molecule drawing it into the cavity of the cyclodextrin where additional non-covalent attractions (⇔) hold the molecule securely in place. Reproduced with permission.122 British Journal of Anaesthesia  , DOI: ( /bja/aep093) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions


Download ppt "Reversal of neuromuscular block"

Similar presentations


Ads by Google