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Autophagy Captures the Nobel Prize

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Presentation on theme: "Autophagy Captures the Nobel Prize"— Presentation transcript:

1 Autophagy Captures the Nobel Prize
Sharon A. Tooze, Ivan Dikic  Cell  Volume 167, Issue 6, Pages (December 2016) DOI: /j.cell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Autophagosomes
Transmission electron microscopy was fundamental for the identification of the cytosolic autophagosomes in yeast by Yoshinori Ohsumi’s group in 1994 (reproduced with permission from Figure 2 in Baba et al., J. Cell Bio. 124, 903–913). Cell  , DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

3 Figure 2 The Impact of Autophagy on Health
A simplified representation of autophagy delivery of cargoes to the lysosome. Autophagosomal membranes are able to surround specific cargoes including damaged mitochondria, protein aggregates, pathogens, or defective organelles and deliver them to the lysosome to regulate cell homeostasis and defend cellular integrity. Deregulation of autophagy results in the development of numerous human diseases. Cell  , DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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