1. Supplementary Figure S1
Supplementary Figure S1. Waterfall Plot Chart: Tumor Size Variation(%) from Baseline during YS110 Administration in First Cycle
55.6
50.0
27.6
26.3
21.3
20.2
19.3
16.2
14.8
11.3
11.2
8.7
8.5
6.7
6.1
4.0
2.3
2.1
2.0
0.0
-0.5
-1.3
-2.4
-2.6
-7.5
-20
-10 10 20 30 40 50 60
0308
0203
0204
0401
0109
0110
0102
0205
0101
0103
0111
0409
0501
0108
0403
0306
0405
0107
0503
0402
0304
0302
0301
0104
0502
Percent Change from Baseline in First Cycle
Unit :　%
PD 12cases
SD 13cases * † **
(47)
(59)
(39)
(42)
(43)
(40)
(41)
(83)
(35)
(98)
(184)
(273)
(33)
(230)
(399)
(223)
(258)
(57)
* : Mesothelioma
Subject
** : Renal cell carcinoma
† : urothelial carcinoma
( ) : PFS (days)

2. Supplementary Figure S2. Kaplan meier Plot : Progression-Free Survival
Group :
0.0
0.2
0.4
0.6
0.8
1.0 28 56 84
112
140
168
196
224
252
280
308
336
364
392
All Groups: 26cases*
* : one case No.0106(mesothelioa) eligible for PFS analysis was involved, therefore, total cases were 26 cases.
Survival Distribution Function
: Censored
Progression Free Survival Time (days)
Quartiles Estimate
Upper
Group
Quartiles
Estimate
Lower
All Groups 75
184 57
258 50 43 40 59 25 39 15 41
Tow-Sided 95% Confidence Interval