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Yoav Gilad, Carlos D. Bustamante, Doron Lancet, Svante Pääbo 

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Presentation on theme: "Yoav Gilad, Carlos D. Bustamante, Doron Lancet, Svante Pääbo "— Presentation transcript:

1 Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees 
Yoav Gilad, Carlos D. Bustamante, Doron Lancet, Svante Pääbo  The American Journal of Human Genetics  Volume 73, Issue 3, Pages (September 2003) DOI: /378132 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Ka/Ks values for OR genes and pseudogenes in human and chimpanzee. Values for polymorphic and fixed sites are plotted as unblackened and blackened bars, respectively. The American Journal of Human Genetics  , DOI: ( /378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Marginal posterior distribution of the directional selection parameter (γ=2Nes) on amino acid replacement mutations. A, Chimpanzee intact OR genes and pseudogenes. B, Human intact OR genes and pseudogenes. The American Journal of Human Genetics  , DOI: ( /378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

4 Figure 3 The joint distribution of γ and logω, as estimated from the MCMC scheme. A, Chimpanzee OR pseudogenes. B, Chimpanzee intact OR genes. C, Human OR pseudogenes. D, Human intact OR genes. The American Journal of Human Genetics  , DOI: ( /378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

5 Figure 4 Joint distribution of the scaled selection coefficient (2Ns) that is associated with mutations in OR genes and species divergence parameters (in units of τ). The American Journal of Human Genetics  , DOI: ( /378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

6 Figure 5 Three OR genes studied on human chromosome 11. Rectangles represent the OR coding regions along the chromosome. Indicated are P value of the H test, P(H); Tajima’s D value; and nucleotide diversity, π. The American Journal of Human Genetics  , DOI: ( /378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions


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