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Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries  Atsushi Iwakura,

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Presentation on theme: "Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries  Atsushi Iwakura,"— Presentation transcript:

1 Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries  Atsushi Iwakura, MD, Yasuhiko Tabata, PhD, Tadaaki Koyama, MD, Kazuhiko Doi, MD, Kazunobu Nishimura, MD, Kazuaki Kataoka, MD, Masatoshi Fujita, MD, Masashi Komeda, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 126, Issue 4, Pages (October 2003) DOI: /S (03)

2 Figure 1 Sternal scintiscans with 99mTc-MDP 4 weeks after surgical intervention showing increased uptake in the FGF group (A) and reduced uptake in the control group (B). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03) )

3 Figure 2 Quantitative analysis of sternal uptake 30 and 60 minutes after the injection of 99mTc-MDP 4 weeks after surgical treatment of the FGF and control groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03) )

4 Figure 3 Micrographs stained with hematoxylin and eosin showing new blood vessel formation in connective tissue around the sternum 4 weeks after surgical treatment of the FGF (A) and control (B) groups. Increased numbers of capillaries and arterioles are indicated (arrowheads). NB, New bone. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03) )

5 Figure 4 Quantitative analysis of the number of vessels in connective tissue around the sternum 4 week after surgical treatment of the FGF and control groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03) )

6 Figure 5 Radiograph showing sternal bone regeneration 4 weeks after surgical treatment in dogs. A, Almost complete sternal regeneration was seen in the FGF group. B, Obvious sternal dehiscence was observed in the control group (arrowheads). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03) )

7 Figure 6 Histologic cross-sections of azan-stained sternum were obtained 4 weeks after surgical treatment. Whole sternal feature in the FGF (A) or control (B) groups was shown at a low magnification (2×). Regenerated sternal bone was observed along the incision line of the sternum only in the FGF group (C). Fibrous tissue instead of regenerated bone invaded the space between the separated original sternum (D). OS, Original sternum; NB, new bone. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03) )

8 Figure 7 BMC (left) and BMD (right) were analyzed on the whole sternum and along the sternal median incision line (60 × 1 mm2 ROI) by means of dual-energy x-ray absorptometry after surgical treatment of the FGF and control groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (03) )

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