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Achieving Lipid Targets With PCSK9 Inhibition

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Presentation on theme: "Achieving Lipid Targets With PCSK9 Inhibition"— Presentation transcript:

1 Achieving Lipid Targets With PCSK9 Inhibition

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4 Achieved LDL < 50 mg/dL Has a Greater Relative Risk Reduction Than Higher Levels

5 IMPROVE-IT Efficacy

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7 ODYSSEY HIGH FH

8 Alirocumab and Evolocumab European Labelling and Indications

9 Alirocumab and Evolocumab US Labelling and Indications

10 GAUSS-2 Study of Evolocumab in Statin-Intolerant Patients % Change in LDL-C From Baseline at Week 12

11 Statin Myopathy is a Common Challenge in Lipid Management

12 Therapy for Statin Intolerance

13 Long-term Outcomes of Lipid-Lowering in FH

14 FH Starts Before Birth

15 Efficacy and Safety of Alirocumab in Individuals With Diabetes

16 New Onset Diabetes Mellitus (NODM) in IMPROVE-IT

17 Alirocumab Effect on Glycemic Measures in Patients Without Diabetes

18 PCSK9 Knockdown by RNAi

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20 dal-OUTCOMES Dalcetrapib Did Not Reduce Risk of Recurrent CV Events

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22 Abbreviations

23 Abbreviations (cont)


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