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Dawn H. Loh, Takashi Kudo, Christopher S. Colwell  Neuron 

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Presentation on theme: "Dawn H. Loh, Takashi Kudo, Christopher S. Colwell  Neuron "— Presentation transcript:

1 Short Circuiting the Circadian System with a New Generation of Precision Tools 
Dawn H. Loh, Takashi Kudo, Christopher S. Colwell  Neuron  Volume 85, Issue 5, Pages (March 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic Illustrating the Key Findings
In this highly stylized representation, AVP-expressing neurons are localized in the shell region of the SCN while NMS-expressing neurons are localized throughout the nucleus. NMS (blue) appear to be co-expressed with the majority of AVP (green) and VIP (orange) expressing neurons. Disrupting the molecular clock in NMS or AVP neurons produced abnormal circadian rhythms. Lengthening the intracellular circadian period of NMS neurons lengthens behavioral circadian period. Blocking synaptic transmission from NMS neurons similarly leads to the loss of coherent circadian rhythms. These phenotypes were reversible with appropriate genetic manipulations. Neuron  , DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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