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Determinants of glomerular hypofiltration in aging humans

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Presentation on theme: "Determinants of glomerular hypofiltration in aging humans"— Presentation transcript:

1 Determinants of glomerular hypofiltration in aging humans
Khoi Hoang, Jane C. Tan, Geraldine Derby, Kristina L. Blouch, Marilyn Masek, Irene Ma, Kevin V. Lemley, Bryan D. Myers  Kidney International  Volume 64, Issue 4, Pages (October 2003) DOI: /j x Copyright © 2003 International Society of Nephrology Terms and Conditions

2 Figure 1 Glomerular filtration rate (GFR) plotted as a function of age in 164 healthy individuals. Symbols are: (○) males; (▴) females. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

3 Figure 2 Renal plasma flow (RPF) (A) as a function of age and mean arterial pressure (MAP) (B) as a function of age. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

4 Figure 3 Two-kidney ultrafiltration coefficient (Kf) for ΔP = 40mm Hg in youthful (<40 years) and ΔP = 40 or 45mm Hg in aging subjects (≥55 years).*P < vs. youthful. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

5 Figure 4 Percent of global glomerulosclerosis in biopsies of youthful (<40 years) and aging (≥55 years) healthy subjects. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

6 Figure 5 Filtration slit frequency (FSF) (A) and filtration surface density (SV) (B) as a function of age in healthy subjects. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

7 Figure 6 Hydraulic permeability (k) (A), filtration surface area (S) (B), and single-nephron ultrafiltration coefficient (SNKf) (C) in youthful (<40 years) vs. aging (≥55 years) subjects.*P < 0.05; †P = 0.09 vs. youthful group. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions


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