1. How to organize a journal club?
Prof. P. Devroey

2. Definition A group of individuals meeting regularly
Critical evaluation of recent articles
In the academic literature
Organized around a defined topic

3. Technology Appropriateness of the study design
Evaluation of the statistics
Evaluation of the controls
Discussion on results
Design of new research

4. Purpose To make students/practicioners familiar with advanced research
To better understand
To debate current topics
Evaluation of the journal

5. New technology Online communication Using Twitter Web applications
i.e. British Journal of Obstetrics and Gynaecology, Primary Care Medicine…

6. Approval of the written documents of the previous meeting
Methodology
On a regular basis
i.e. once a month
One leader
Written documents
One topic
Approval of the written documents of the previous meeting

7. Which type of general topics?
How to do a study?
How to do statistics?
How to do a randomized controlled trial?
How to do a review?
How to define evidence?

8. How to write an abstract?
How to give a lecture?
How to write a paper?
How to organize an ethics committee? …

9. Hirsch factor Proposed in 2005 by Jorge E. Hirsch Author-level metric
Productivity and citation impact of the publications
Based on the most cited papers
Can be applied to evaluate the impact of a journal, group of scientists or an individual

10. Systematic reviews Systematic reviews Cochrane Evidence
Implication for daily practice
Organization of study design

11. Proposals for study designs (1)
Randomized controlled trial
Two arms
Delivery rate per started cycle without PGS
Delivery rate per started cycle with PGS
Result?

12. Last article published in 2008 Result
Pubmed
Last article published in 2008
Result
Delivery rates with live birth per started cycle were not significantly different.

13. Proposals for study designs (2)
Randomized controlled trial
Day 3 or day 5 embryo replacements IVF/ICSI
Result?

14. Pubmed
Last article published in 2012
There was no difference in clinical pregnancy rate between early cleavage and blastocyst transfer in the 23 RCTs (Peto OR 1.14, 95% CI 0.99 to 1.32) (Day 2 to 3: 38.6%; Day 5 to 6: 41.6%)

15. Proposal for study designs (3)
Randomized controlled trial
The luteal phase supplementation with progesterone alone or progesterone and oestradiol valerate
Result?

16. Pubmed
Last one published in 2016
In conclusion, the addition of 4 mg estrogen daily to progesterone for luteal support in antagonist ICSI cycles is not beneficial for pregnancy outcome.

17. More questions
Pregnancy rates after single or double ET per started cycle?
Pregnancy rates after assisted hatching versus no assisted hatching?
Pregnancy rates after luteal progesterone in clomid cycles? …

18. Conclusion Urgent need for searching evidence based medicine
Organization of evidence based medicine
Implementation of local ethical review board
Organization of journal club
Following the results of the randomized controlled trials