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Assessment of Therapy Responses and Prediction of Survival in Malignant Pleural Mesothelioma Through Computer-Aided Volumetric Measurement on Computed.

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Presentation on theme: "Assessment of Therapy Responses and Prediction of Survival in Malignant Pleural Mesothelioma Through Computer-Aided Volumetric Measurement on Computed."— Presentation transcript:

1 Assessment of Therapy Responses and Prediction of Survival in Malignant Pleural Mesothelioma Through Computer-Aided Volumetric Measurement on Computed Tomography Scans  Fan Liu, PhD, Binsheng Zhao, DSc, Lee M. Krug, MD, Nicole M. Ishill, MS, Remy C. Lim, MD, Pingzhen Guo, MD, Matthew Gorski, BA, Raja Flores, MD, Chaya S. Moskowitz, PhD, Valerie W. Rusch, MD, Lawrence H. Schwartz, MD  Journal of Thoracic Oncology  Volume 5, Issue 6, Pages (June 2010) DOI: /JTO.0b013e3181dd0ef1 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Circumferential and irregular shape of malignant pleural mesothelioma showed limitations of 2D measurement (arrows). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181dd0ef1) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Computer segmentation of tumor corrected by radiologist. A, computer result on original image with suboptimal segmentation and inclusion of other tissues (arrows). B, manual correction on computer result. C and D, 3D rendering of the baseline alignant pleural mesothelioma (MPM) volume (596 cc) and the first follow-up MPM volume (208 cc). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181dd0ef1) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Overall survival curve.
Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181dd0ef1) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Survival analysis of baseline and early follow-up. A, patients with small MPM volume in baseline tends to survival longer (p = 0.07). B, patients whose MPM volume decreased in early follow-up and longer survival (p = 0.03). Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181dd0ef1) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

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