1. Biomarkers identified with time-lapse imaging: discovery, validation, and practical application 
Alice A. Chen, Ph.D., Lei Tan, Ph.D., Vaishali Suraj, M.S., Renee Reijo Pera, Ph.D., Shehua Shen, M.D. 
Fertility and Sterility 
Volume 99, Issue 4, Pages (March 2013)
DOI: /j.fertnstert
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
Time-lapse markers used for clinical outcome predictions in published studies. Landmark events captured by time-lapse imaging are mapped to the progression of preimplantation embryo development. Time-lapse markers that have been used for prediction in at least three publications are colored dark red while others are colored light red. Average values for embryo outcomes within the prediction windows are labeled above colored bars.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

3. Figure 2
Time-lapse markers used for blastocyst prediction by the 4-cell stage in basic and molecular research (A) and a multicenter clinical validation study (B). Plots show that blastocysts mostly cluster tightly in a specific region for first cytokinesis duration (P1), the time between first and second mitosis (P2), and the time between the second and third mitosis (P3), while arrested embryos are mostly scattered. The time-lapse markers are plotted in units of hours.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions