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Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort  Emily C. McGowan, MD, Gordon R. Bloomberg, MD,

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Presentation on theme: "Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort  Emily C. McGowan, MD, Gordon R. Bloomberg, MD,"— Presentation transcript:

1 Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort  Emily C. McGowan, MD, Gordon R. Bloomberg, MD, Peter J. Gergen, MD, MPH, Cynthia M. Visness, PhD, MPH, Katy F. Jaffee, MS, Megan Sandel, MD, George O'Connor, MD, Meyer Kattan, MD, James Gern, MD, Robert A. Wood, MD  Journal of Allergy and Clinical Immunology  Volume 135, Issue 1, Pages e4 (January 2015) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Percentage of children classified as having FA (group 1) during each year of follow-up in the URECA cohort. Children were characterized as having FA if they had serologic and clinical evidence of allergy to the food and documentation of food avoidance during that year. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Differences in food-specific IgE levels between those classified as being in group 3 (sensitized but not allergic, red) and group 1 (FA, blue) at ages 1, 2, 3, and 5 years. Significant differences (P < .05) were noted for egg at age 1 and 2 years and are depicted with an asterisk. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Food-specific IgG4 levels among those in groups 4 (green), 3 (red), and 1 (blue) at ages 1 and 3 years. Significant differences between groups (P < .05) are noted with a line and asterisk. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 OR for development of FA (left panel) or food sensitization (right panel) for summary variables of PBMC cytokine response. Allergic, Group 1 (FA) versus groups 3 (sensitized but tolerant) and 4 (not sensitized). Sensitized, Groups 1, 2 (possibly food allergic), and 3 versus group 4. Solid circles represent statistical significance in models adjusted for site, sex, and season of birth. A, Innate panel. B, Adaptive panel. See Table E1 for abbreviation definitions and a list of stimulants and cytokines measured. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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