Download presentation
Presentation is loading. Please wait.
1
Volume 38, Issue 1, Pages 44-50 (January 2003)
Nitric oxide mediates the reduced vasoconstrictor response to angiotensin II in patients with preascitic cirrhosis Ahmed Helmy, David Ernest Newby, Rajiv Jalan, Neil Russell Johnston, Peter Clive Hayes, David John Webb Journal of Hepatology Volume 38, Issue 1, Pages (January 2003) DOI: /S (02)
2
Fig. 1 Schematic diagram of the six phases of the study protocol. F, bilateral FBF measurements each for 3 min; *, time for blood sampling; #, time for assessment of systemic hemodynamics using electrical bioimpedance. ANG-II doses are 3, 10 and 30 pmol min−1. The l-NMMA dose is 4 μmol min−1. SNP was infused at titrated doses ranging from 80 to 600 ng min−1. Journal of Hepatology , 44-50DOI: ( /S (02) )
3
Fig. 2 Percentage change in FBF in response to l-NMMA infusion (4 μmol min−1) in cirrhotic patients (□) and controls (○). P<0.001 from baseline 1 in both groups. P>0.05, cirrhotic patients vs. controls, two-way ANOVA with replication. Journal of Hepatology , 44-50DOI: ( /S (02) )
4
Fig. 3 FBF responses to incremental doses of ANG-II (pmol min−1) in cirrhotic patients (squares) and controls (circles) before the ‘NO-clamp’ (open symbols) and during the ‘NO-clamp’ (solid symbols). P<0.001, dose–response in each phase by one-way ANOVA. Cirrhotics vs. controls: P=0.012 before clamp; P=0.57 during clamp (two-way ANOVA with repeated measures). Before clamp vs. during clamp: P<0.001 in cirrhotics; P=0.75 in controls (two-way ANOVA with repeated measures). Journal of Hepatology , 44-50DOI: ( /S (02) )
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.