1. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency

2. Introduction

3. GENETICS
INHERITANCE
RACE

4. RACE

5. INHERITANCE G6PD dehydrogenase gene is carried on the X chromosome
Females produce the same amount of G6PD enzyme as males
There are variant alleles of the G6PD gene

6. 18.5
Size of gene (in kilobases)
DNA 13
Number of exons 12
Number of introns
2269
Size (in nucleotides)
mRNA
515
Number of amino acids
Protein
59,265
Molecular weight (in Daltons)
2 or 4
Subunits per molecule of active enzyme

7. The G6PD enzyme catalyzes an oxidation/reduction reaction

9. CLINICAL ASPECTS
NEONATAL JAUNDICE
HEMOLYTIC ANEMIA
MALARIA RESISTANCE

10. Definition Causes Complications Diagnosis Treatment
NEONATAL JAUNDICE
Complications
Diagnosis
Treatment

13. DRUG-INDUCED HEMOLYTIC ANEMIA FAVA BEAN-INDUCED HEMOLYTIC ANEMIA

14. DRUG-INDUCED HEMOLYTIC ANEMIA
Medications that expose
RBCs to higher than normal amounts of
Oxidative stress
DRUG-INDUCED HEMOLYTIC ANEMIA

15. Infection-Fighting Drugs
Aspirin
Certain Medications
Infection-Fighting Drugs
Sulfonamides
Antimalarial Drugs
Chloroquine
Quinine
Primaquine

16. FAVA BEAN-INDUCED HEMOLYTIC ANEMIA Divicine and Isouramil
Vicine and Convicine
Divicine and Isouramil

18. MALARIA RESISTANCE