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Linearity and Stability of Intravenous Busulfan Pharmacokinetics and the Role of Glutathione in Busulfan Elimination  Shlomo Almog, Daniel Kurnik, Avichai.

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Presentation on theme: "Linearity and Stability of Intravenous Busulfan Pharmacokinetics and the Role of Glutathione in Busulfan Elimination  Shlomo Almog, Daniel Kurnik, Avichai."— Presentation transcript:

1 Linearity and Stability of Intravenous Busulfan Pharmacokinetics and the Role of Glutathione in Busulfan Elimination  Shlomo Almog, Daniel Kurnik, Avichai Shimoni, Ronen Loebstein, Eyal Hassoun, Asher Gopher, Hillel Halkin, Arnon Nagler  Biology of Blood and Marrow Transplantation  Volume 17, Issue 1, Pages (January 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Reduction of pretreatment whole blood GSH concentration in patients receiving RIC and MAC protocols. The second GSH concentration was measured on day 2 (after a cumulative dose of 3.2 mg/kg) in patients on an RIC protocol and on day 3 (after a cumulative dose of 6.4 mg/kg) in patients on an MAC protocol. Horizontal lines represent the median. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Correlation of baseline GSH whole blood concentration and Bu clearance. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions


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