1. (A) Observed significant protein fold‐changes during the fed–fasting transition in C57BL/6J (B6) and 129Sv (S9) mice fed with a normal diet (T0).
(A) Observed significant protein fold‐changes during the fed–fasting transition in C57BL/6J (B6) and 129Sv (S9) mice fed with a normal diet (T0). Significance threshold was set at adjusted P‐value of (B) Scatter plot of P‐values associated with the observed changes when comparing both mouse strains fed in normal diet—i.e., 0 weeks (T0, x axis); and after 12 weeks of high‐fat diet (T2, y axis). The plot is divided into three main parts: (i) proteins with a different fasting‐response pattern at normal diet (blue dots); (ii) proteins with a different fasting response among strains only after 12 weeks of high‐fat diet (green dots); and (iii) proteins with a different fasting response both in normal diet and after 12 weeks of high‐fat diet (red dots). (C) Protein abundance changes in the fed–fasting transition of selected proteins at 0 (T0) and 12 (T2) weeks of high‐fat diet for each mouse strain (B6, blue; S9, pink). Error bars correspond to standard errors.
Eduard Sabidó et al. Mol Syst Biol 2013;9:681
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