1. Remifentanil–sevoflurane interaction models of circulatory response to laryngoscopy and circulatory depression 
S.S. Bi, C.H. Deng, T.Y. Zhou, Z. Guan, L. Li, H.Q. Li, L.P. Zhang, L. Yang, W. Lu 
British Journal of Anaesthesia 
Volume 110, Issue 5, Pages (May 2013)
DOI: /bja/aes504
Copyright © 2013 The Author(s) Terms and Conditions

2. Fig 1
Observed and predictions of the relationship between sevoflurane and remifentanil and probability of pharmacodynamic effects. (a) Response surface for the absence of circulatory response to laryngoscopic stimuli. (b) Response surface for circulatory depression (side-effect). The points represent raw probabilities. (c) Concentration–response curve of plot (a). (d) Concentration–response curve of plot (b).
British Journal of Anaesthesia  , DOI: ( /bja/aes504)
Copyright © 2013 The Author(s) Terms and Conditions

3. Fig 2
Correlations between I(Q) and combined concentrations of sevoflurane and remifentanil with respect to no circulatory response to laryngoscopy and circulatory depression (side-effect). (a) Three-dimensional representation of I(Q) vs the combinations of the two drugs for no circulatory response to laryngoscopy. (b) Three-dimensional representation of I(Q) vs the combinations of the two drugs for circulatory depression. (c) Two-dimensional representation of I(Q) vs the combinations of the two drugs. The blue triangles represent no circulatory response to laryngoscopy and the green squares represent circulatory depression (side-effect).
British Journal of Anaesthesia  , DOI: ( /bja/aes504)
Copyright © 2013 The Author(s) Terms and Conditions

4. Fig 3
Synergistic relationship between the concentration of remifentanil and required perioperative concentrations of sevoflurane. The green and blue circles represent ratios of reduction in the required amount of sevoflurane with respect to no response to laryngoscopic and inducing circulatory depression, respectively.
British Journal of Anaesthesia  , DOI: ( /bja/aes504)
Copyright © 2013 The Author(s) Terms and Conditions

5. Fig 4
The diagnostic plots of the response surface models with respect to the prevention of circulatory response to laryngoscopic stimuli (left panels) and of circulatory depression (right panels). (a) and (b) Weighted residuals (WRES) vs the individual predicted probability of response surface models and vs concentration of sevoflurane. (c) and (d) Scatter plots of observations vs the population predictions and individual predictions. Circles represent individual observations and the lines represent unity.
British Journal of Anaesthesia  , DOI: ( /bja/aes504)
Copyright © 2013 The Author(s) Terms and Conditions

6. Fig 5
Results of visual predictive checks of the final response surface model with respect to the probability of preventing circulatory response to laryngoscopic stimuli (a) and preventing circulatory depression (b). The points represent the median probabilities of observed. The orange lines represent 50% and the orange lines represent 2.5 and 97.5% probabilities of simulated data.
British Journal of Anaesthesia  , DOI: ( /bja/aes504)
Copyright © 2013 The Author(s) Terms and Conditions