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Making the diagnosis of Alport's syndrome

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Presentation on theme: "Making the diagnosis of Alport's syndrome"— Presentation transcript:

1 Making the diagnosis of Alport's syndrome
Yves Pirson  Kidney International  Volume 56, Issue 2, Pages (August 1999) DOI: /j x Copyright © 1999 International Society of Nephrology Terms and Conditions

2 Figure 1 Tonal audiometry showing a bilateral, symmetric loss (in decibels or dB) most marked in high tones (1000–8000 Hertz). Hatched rectangle is the area of conversational speech. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

3 Figure 2 Electron photomicrograph of glomerular basement membrane, showing segments of thickening and thinning with irregular contours (left panel). Magnification of a thickened segment showing lamellation, electron-lucent areas and electron-dense granules (right panel). Courtesy of Dr. J.P. Cosyns. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

4 Figure 3 Immunostaining of the nephrectomy spectrum with antiα5 (IV) antibodies, showing expression in basement membranes of collecting ducts. Courtesy of Dr. M.C. Gubler. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

5 Kidney International 1999 56, 760-775DOI: (10. 1046/j. 1523-1755. 1999
Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions


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