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Lamivudine in hepatitis B-associated membranous nephropathy

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Presentation on theme: "Lamivudine in hepatitis B-associated membranous nephropathy"— Presentation transcript:

1 Lamivudine in hepatitis B-associated membranous nephropathy
Sydney Tang, Fernand Mac-Moune Lai, Yun Hoi Lui, Colin S.O. Tang, Nelson N.S. Kung, Yiu Wing Ho, Kwok Wah Chan, Joseph C.K. Leung, Kar Neng Lai  Kidney International  Volume 68, Issue 4, Pages (October 2005) DOI: /j x Copyright © 2005 International Society of Nephrology Terms and Conditions

2 Figure 1 Characteristic features of HBV-associated membranous nephropathy. (A) Representative electron micrograph of MN from one of the subjects in group 1, showing the typical presence of both subepithelial (more numerous) and subendothelial electron-dense deposits (×13,000). (B) Positive granular staining along the glomerular capillary wall in immunofluorescence study with polyclonal anti-HBc (×300). (C) Viral-like particles (arrows) appearing as clusters of round to ovoid structures of 10 to 30 nm in diameter and varying density distributed with the glomerular capillary basement membrane electron-dense deposits (×30,000). Kidney International  , DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions

3 Figure 2 Blood pressure control during follow-up.
Kidney International  , DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions

4 Figure 3 Change in urinary protein excretion rates in lamivudine-treated (group 1) and control subjects (group 2). Results are expressed as mean ± SE. *P = vs. baseline values. †P = 0.011, ‡P = 0.034, §P = 0.07 vs. the corresponding time point in group 1. Kidney International  , DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions

5 Figure 4 Fluctuation in ALT levels. Data are expressed as mean ± SE. *P = 0.019, †P = 0.028, ‡P = vs. baseline values. Kidney International  , DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions

6 Figure 5 Kaplan-Meier analysis of renal survival in patients who received (solid line) and did not receive (dotted line) lamivudine treatment for HBV-associated MN. Kidney International  , DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions

7 Figure 6 Change in serum creatinine over time. To convert serum creatinine in mg/dL into μmol/L, multiply by 88.4. Kidney International  , DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions


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