1. Apoptosis in ischemic renal injury: Roles of GTP depletion and p53
Pierre C. Dagher 
Kidney International 
Volume 66, Issue 2, Pages (August 2004)
DOI: /j _7.x
Copyright © 2004 International Society of Nephrology Terms and Conditions

2. Figure 1
Guanosine triphosphate (GTP) depletion and p53 in ischemia-induced apoptosis. This model proposes that GTP depletion and the activation of p53 are sequential steps underlying the apoptotic phenotype seen after renal ischemia. Guanosine and pifithrin-alpha restore GTP and inhibit p53, respectively, thus preventing apoptosis.
Kidney International  , DOI: ( /j _7.x)
Copyright © 2004 International Society of Nephrology Terms and Conditions