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POLG defects cause degeneration of enhancer‐active regions of CNS

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Presentation on theme: "POLG defects cause degeneration of enhancer‐active regions of CNS"— Presentation transcript:

1 POLG defects cause degeneration of enhancer‐active regions of CNS
POLG defects cause degeneration of enhancer‐active regions of CNS Spinal cord (C8 level) of MIRAS patient, neurofilament staining. Dorsal columns, especially the gracile, show pallor (dashed line with star); motoneurons in the anterior horns are preserved (dashed line with black arrow). Scale bar 1 mm.Oculomotor complex of POLG patient with progressive ophthalmoplegia; midbrain level. Hematoxylin–eosin staining. The whole area shows spongiotic degeneration. Scale bar 50 μm. Joni Nikkanen et al. EMBO Mol Med. 2017;emmm © as stated in the article, figure or figure legend


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