1. MOMENTUM 3
Trial design: Patients with advanced heart failure were randomized to a centrifugal-flow pump (n = 152) vs. an axial-flow pump (n = 142).
Results
(p = 0.04)
Freedom from disabling stroke or reoperation to replace/remove the device at 6 months: 86.2% of the centrifugal-flow pump group vs. 76.8% of the axial-flow pump group (p < for noninferiority; p = 0.04 for superiority)
Pump thrombosis: 0% vs. 10.1%; respectively, for centrifugal vs. axial pump
86.2
76.8 %
Conclusions
Among patients with heart failure requiring advanced mechanical support, a centrifugal-flow LVAD was associated with better outcomes compared with an axial-flow LVAD
Benefit was primarily due to a reduction in pump malfunction and pump thrombosis
Centrifugal-flow
Axial-flow
Mehra MR, et al. N Engl J Med 2016;Nov 16:[Epub]