1. Pairs / trio’s 200 families with 2 offspring, 224 with 3 offspring
200 pairs & 224 trios = *224= = 872 pairs
(and is = 1072 subjects)
QTL analysis (A = 40%, E = 30%, Q = 10%)
Analysis of 424 complete families: chi-square = (df =1)
Analysis of 872 pairs: chi-square = 2.293

2. Pairs / trio’s; all possible pairs vs whole family
One family with 2 members generates 1 pair
One family with 2 members generates 3 pairs
One family with 4 members generates 6 pairs
Etc..
In Mx you can easily model multiple sibs in a fami

3. Pairs / trio’s; all possible pairs vs whole family
200 families with 2 offspring, 224 with 3 offspring
200 pairs & 224 trios = *224= = 872 pairs
(and is = 1072 subjects)
QTL analysis (A = 40%, E = 30%, Q = 10%)
Analysis of 424 complete families: chi-square = (df =1)
Analysis of 872 pairs: chi-square = 2.293