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Pressure distension stimulates the expression of endothelial adhesion molecules in the human saphenous vein graft  Massimo Chello, MD, Pasquale Mastroroberto,

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Presentation on theme: "Pressure distension stimulates the expression of endothelial adhesion molecules in the human saphenous vein graft  Massimo Chello, MD, Pasquale Mastroroberto,"— Presentation transcript:

1 Pressure distension stimulates the expression of endothelial adhesion molecules in the human saphenous vein graft  Massimo Chello, MD, Pasquale Mastroroberto, MD, Giacomo Frati, MD, Giuseppe Patti, MD, Andrea D’Ambrosio, MD, Germano Di Sciascio, MD, Elvio Covino, MD  The Annals of Thoracic Surgery  Volume 76, Issue 2, Pages (August 2003) DOI: /S (03)

2 Fig 1 (A) Scanning electron microscopy of control vein with almost intact endothelial layer (N = nucleus). Areas of endothelial denudation (arrow) with partly detached cells are present after pressure distension (C). The Annals of Thoracic Surgery  , DOI: ( /S (03) )

3 Fig 2 Percent expression of intercellular adhesion molecule–1 (ICAM-1), vascular cell adhesion molecule–1 (VCAM-1), and P-selectin on the endothelial cells of control and dilated saphenous vein grafts. Bars represent mean number (± SEM) of positive staining segments per area examined, with filled bars indicating control and open bars dilated saphenous vein grafts. (*p < 0.01 versus control vein.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

4 Fig 3 Immunohistochemical analysis of intercellular adhesion molecule-1 expression on the endothelium of human saphenous vein. Staining was negative on endothelial cells of control vein (a), but it increased significantly (arrows) on the endothelial cells of distended vein (b). The Annals of Thoracic Surgery  , DOI: ( /S (03) )

5 Fig 4 Immunohistochemical analysis of P-selectin expression on endothelium of human saphenous vein. Staining was only weakly positive on endothelial cells of control veins (a), but it increased significantly (arrows) on endothelial cells of distended veins (b). The Annals of Thoracic Surgery  , DOI: ( /S (03) )

6 Fig 5 Adhesion of both unstimulated and activated polymorphonuclears (PMNs) to endothelium of either dilated or control veins, under normal conditions and after treatment with blocking monoclonal antibodies (mAb) to vascular cell adhesion molecule–1 (VCAM-1), intercellular adhesion molecule–1 (ICAM-1), P-selectin (P-sel), and P-selectin plus ICAM-1. Bars indicate mean values ± SEM, with filled bars representing control and open bars dilated veins. (*p < 0.01 versus control vein.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

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