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Volume 77, Issue 1, Pages (January 2010)

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1 Volume 77, Issue 1, Pages 23-28 (January 2010)
Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease  Rocco Barazzoni, XinXia Zhu, Mark DeBoer, Rakesh Datta, Michael D. Culler, Michela Zanetti, Gianfranco Guarnieri, Daniel L. Marks  Kidney International  Volume 77, Issue 1, Pages (January 2010) DOI: /ki Copyright © 2010 International Society of Nephrology Terms and Conditions

2 Figure 1 Mitochondrial enzyme activities. Skeletal muscle activities of cytochrome c oxidase (COX) (a) and citrate synthase (CS) (b) in the experimental groups; *P<0.05. Ghr, ghrelin; Neph, nephrectomy; PF, pair-feeding; S, saline. Kidney International  , 23-28DOI: ( /ki ) Copyright © 2010 International Society of Nephrology Terms and Conditions

3 Figure 2 Mitochondrial biogenesis and lipid metabolism regulators. Skeletal muscle transcript levels of peroxisome proliferator-activated receptor-γ coactivator 1-α (a; PGC1-α), peroxisome proliferator-activated receptor-γ coactivator 1-β (b; PGC1-β), mitochondrial transcription factor A (c; mTFA), peroxisome proliferator-activated receptor-α (d; PPAR-α) in the experimental groups; *P<0.05. Ghr, ghrelin; Neph, nephrectomy; PF, pair-feeding; S, saline. Kidney International  , 23-28DOI: ( /ki ) Copyright © 2010 International Society of Nephrology Terms and Conditions

4 Figure 3 Muscle triglycerides and AKT phosphorylation. Skeletal muscle triglycerides (a) and the ratio (P/T) of phosphorylated (P) to total (T) AKT protein (b) in the experimental groups. Representative bands from western blotting for P- and T-AKT are shown under each bar. *P<0.05. Ghr, ghrelin; Neph, nephrectomy; PF, pair-feeding; S, saline. Kidney International  , 23-28DOI: ( /ki ) Copyright © 2010 International Society of Nephrology Terms and Conditions


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