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Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody  Voravit Ratanatharathorn, Lois Ayash, Christopher Reynolds,

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Presentation on theme: "Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody  Voravit Ratanatharathorn, Lois Ayash, Christopher Reynolds,"— Presentation transcript:

1 Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody 
Voravit Ratanatharathorn, Lois Ayash, Christopher Reynolds, Samuel Silver, Pavan Reddy, Michael Becker, James L.M Ferrara, Joseph P Uberti  Biology of Blood and Marrow Transplantation  Volume 9, Issue 8, Pages (August 2003) DOI: /S (03)

2 Figure 1 This patient (case 1) showed cervical flexion contracture (caused by dense fibrosis of the anterior cervical fascia), blotchy hyperpigmentation, hidebound facial skin, and circumoral stricture. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) )

3 Figure 2 Resolution of the cervical flexion contracture and improvement of the sclerodermoid changes of the facial skin. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) )

4 Figure 3 Painful cyanotic fingers in a patient (case 2) with cold agglutinin. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) )

5 Figure 4 Resolution of painful cyanotic fingers after antibody therapy. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) )

6 Figure 5 Response of proteinuria in a patient with membranous glomerulonephritis. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) )

7 Figure 6 Response of restrictive or obstructive pulmonary physiology to antibody therapy; (■) forced vital capacity, () forced expiratory volume in 1 second. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) )


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