1. Evaluating Success of Current Treatments for HCM

3. Hypertrophic Cardiomyopathy (HCM)

4. HCM Prevalence

5. Diagnosis Process

6. Identifying HCM

7. Nonspecific Symptoms of HCM

8. MOGE(S) Classification of Cardiomyopathies

9. Heterogeneous HCM -- A Broad Term

10. Diagnostic Challenges

11. Case Presentation

12. Case Presentation (cont)

13. Case Presentation (cont)

14. Case Presentation (cont)

15. Disease Pathway

16. Obstruction Is Associated With Symptom Progression in HCM

17. Treatment Algorithm for Obstructive HCM

18. Case Presentation (cont) Treatment Approach

19. No HCM-Specific Treatments to Date

20. Nonobstructive HCM

21. More Options for Obstructive HCM Invasive Septal Reduction Therapy

22. Investigational Therapies

23. Mavacamten (MYK-461)

24. PIONEER-HCM (Phase 2 Study) Mavacamten Reduces LVOT Gradients

25. PIONEER-HCM (Phase 2 Study) Improvement in Symptoms and Functional Capacity

26. Ongoing Trials in Obstructive HCM and NOHCM

27. PIONEER-OLE Positive Six-Month Safety and Efficacy Data

28. Conclusion

29. Abbreviations

30. Abbreviations (cont)