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The efficacy and safety of Tipapkinogen Sovacivec therapeutic HPV vaccine in cervical intraepithelial neoplasia grades 2 and 3: Randomized controlled.

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Presentation on theme: "The efficacy and safety of Tipapkinogen Sovacivec therapeutic HPV vaccine in cervical intraepithelial neoplasia grades 2 and 3: Randomized controlled."— Presentation transcript:

1 The efficacy and safety of Tipapkinogen Sovacivec therapeutic HPV vaccine in cervical intraepithelial neoplasia grades 2 and 3: Randomized controlled phase II trial with 2.5 years of follow-up  Diane M. Harper, Pekka Nieminen, Gilbert Donders, Mark H. Einstein, Francisco Garcia, Warner K. Huh, Mark H. Stoler, Katerina Glavini, Gemma Attley, Jean-Marc Limacher, Berangere Bastien, Elizabeth Calleja  Gynecologic Oncology  DOI: /j.ygyno Copyright © 2019 The Authors Terms and Conditions

2 Fig. 1 Trial schematic—700 Patients Screened and subsequent enrollment in the safety population and the modified intent to treat (mITT) population. Gynecologic Oncology DOI: ( /j.ygyno ) Copyright © 2019 The Authors Terms and Conditions

3 Fig. 2 Viral DNA clearance by Roche Linear Array Assay Fig. 2A. Among baseline CIN 2/3 regardless of HR HPV types through month 30, mITT. Fig. 2B. Among baseline CIN 3 regardless of HR HPV types through month 30, mITT. Fig. C. Among baseline CIN 2/3 by HR HPV type through month 30, mITT. Gynecologic Oncology DOI: ( /j.ygyno ) Copyright © 2019 The Authors Terms and Conditions


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