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Corticosteroid-induced apoptosis in mouse airway epithelium: Effect in normal airways and after allergen-induced airway inflammation  Delbert R. Dorscheid,

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Presentation on theme: "Corticosteroid-induced apoptosis in mouse airway epithelium: Effect in normal airways and after allergen-induced airway inflammation  Delbert R. Dorscheid,"— Presentation transcript:

1 Corticosteroid-induced apoptosis in mouse airway epithelium: Effect in normal airways and after allergen-induced airway inflammation  Delbert R. Dorscheid, MD, PhDa, Erika Low, BAb, Amber Conforti, BSb, Seth Shifrin, MDb, Anne I. Sperling, PhDb, Steven R. White, MDb  Journal of Allergy and Clinical Immunology  Volume 111, Issue 2, Pages (February 2003) DOI: /mai Copyright © 2003 Mosby, Inc. Terms and Conditions

2 Fig. 1 Abundance of p85-PARP in airways of mice treated with dexamethasone. Mice were treated daily for 3 or 6 days or 5 days a week for 2 to 4 weeks. The negative control, from a mouse treated for 2 weeks, omitted the primary antibody (bar = 20 μm). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

3 Fig. 2 Presence of eosinophils (A) and epithelial cells (B) in BAL fluid of mice after sensitization and challenge with OVA. Some mice were treated with 1 mg/kg dexamethasone daily starting on day 4 after OVA challenge. Dex, Dexamethasone. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

4 Fig. 3 Abundance of p85-PARP in large intraparenchymal airways 7 to 14 days after sensitization and challenge with OVA. The control mouse was sham sensitized, challenged with OVA, and examined 7 days later. The negative control, from a mouse 7 days after OVA challenge, omitted the primary antibody (bar = 20 μm). Dex, Dexamethasone. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

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