1. Cardiac Allograft Vasculopathy Is Abrogated by Anti-CD8 Monoclonal Antibody Therapy 
James S Allan, Joseph K Choo, Liana Vesga, J.Scott Arn, Michael R Pins, David H Sachs, Joren C Madsen 
The Annals of Thoracic Surgery 
Volume 64, Issue 4, Pages (October 1997)
DOI: /S (97)

2. Fig. 1
Target cell depletion by the anti-CD8 monoclonal antibody The percentage of total peripheral blood lymphocytes (PBL) staining positively for the CD8 surface antigen is plotted with respect to experimental day for all antibody-treated recipients (square = 12091; circle = 12285; star = 12309; diamond = 12279). These data were derived from single-stage flow cytometric analysis using fluorescein isothiocyanate-conjugated Monoclonal antibody was administrated on day 0.
The Annals of Thoracic Surgery  , DOI: ( /S (97) )

3. Fig. 2
Persistence of circulating monoclonal antibody in pig after a single administration of on day 0. The percentage of naive peripheral blood lymphocytes (PBL) reactive with serum from pig is plotted with respect to experimental day (solid line). These data were derived from a two-stage flow cytometric analysis using sera from pig at a 1:100 dilution (first stage) and goat-anti-mouse-fluorescein isothiocyanate (second stage). For comparison, the percentage of total peripheral blood lymphocytes from pig staining positively for CD8 with respect to experimental day (dashed line) has been superimposed. Similar results were obtained for each of the treated recipients.
The Annals of Thoracic Surgery  , DOI: ( /S (97) )

4. Fig. 3
Coronary artery histology from control swine treated with cyclosporine alone. (A) Arteriole from pig stained with van Gieson’s elastin stain (×250 before 48% reduction) and (B) arteriole from pig stained with van Gieson’s elastin stain (×300 before 48% reduction) show intimal thickening due to the deposition of extracellular matrix and the proliferation of spindle cells resulting in luminal occlusion.
The Annals of Thoracic Surgery  , DOI: ( /S (97) )

5. Fig. 4
Coronary artery histology from swine treated with cyclosporine and anti-CD8 monoclonal antibody. (A) Arteriole from pig stained with hematoxylin and eosin (×200 before 48% reduction) and (B) arteriole from pig stained with hematoxylin and eosin (×350 before 48% reduction) show a mild to moderate mononuclear endothelialitis without intimal proliferation.
The Annals of Thoracic Surgery  , DOI: ( /S (97) )