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Polyglactin 910/polydioxanone bicomponent totally resorbable vascular prostheses
Howard P. Greisler, M.D., Eric D. Endean, M.D., John J. Klosak, M.D., Joan Ellinger, James W. Dennis, M.D., Karolyn Buttle, Dae Un Kim, M.D. Journal of Vascular Surgery Volume 7, Issue 5, Pages (May 1988) DOI: / (88)90016-X Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 1 Thickness (in microns) of inner capsule tissues as a function of time after implantation of 74% PG910/26% PDS prostheses, and 100% PG910 prostheses, and 100% PDS prostheses into white New Zealand white rabbit infrarenal aortas. Vertical lines indicate ± 1 SD. Journal of Vascular Surgery 1988 7, DOI: ( / (88)90016-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 2 A, One-month specimen shows PG910 inclusions (V) within macrophages and giant cell cytoplasm. The larger PDS filaments (P) are surrounded but not yet phagocytized by macrophages and giant cells. (Hematoxylineosin stain; original magnification × 550.) B, Transmission electron photomicrograph of midportion of specimen at 2 weeks shows various stages of PG910 inclusions (V) in the cytoplasm of either giant cells or macrophages. Cytoplasmic processes (arrows) are seen infiltrating into the substance of the PG910. (Original magnification × 7800.) Journal of Vascular Surgery 1988 7, DOI: ( / (88)90016-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 3 Midportion of PG910/PDS specimen at 2 months shows inner and outer capsules and residual prosthetic material consisting primarily of PDS (P). Inner capsule tissues are predominantly myofibroblasts and collagen beneath confluent endothelial-like luminal surface. (Hematoxylin-cosin stain; original magnification × 130.) Journal of Vascular Surgery 1988 7, DOI: ( / (88)90016-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 4 Transmission electron photomicrograph of smooth muscle cell-like myofibroblast in inner capsule of 12-month specimen. Abundant myofilaments with dense bodies (arrows) are seen predominantly in peripheral regions of cytoplasm with marked attenuation of rough endoplasmic reticulum. (N = nucleus. Original magnification × 11,000.) Journal of Vascular Surgery 1988 7, DOI: ( / (88)90016-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 5 Transmission electron photomicrograph of midportion of specimen at 12 months shows confluent luminal surface of endothelial cells with tight junctions and numerous pinocytotic vesicles on both apical and basal plasma membranes (original magnification × 7700). Insert, Higher magnification of boxed area shows near-transverse and near-longitudinal sections of rod-shaped microtubulated Weibel-Palade bodies (W-P with arrows) and pinocytotic vesicles (arrowheads). (Original magnification × 74,000.) Journal of Vascular Surgery 1988 7, DOI: ( / (88)90016-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 6 Scanning electron photomicrograph of midportion of specimen at 6 months shows confluent endothelial-like luminal surface. (Original magnification × 400.) Journal of Vascular Surgery 1988 7, DOI: ( / (88)90016-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 7 A, Production of 6-keto-PGF1α by luminal surface of each of six explanted prosthesistissue complexes measured as picograms produced per square millimeter of surface area, as function of time, perfused by culture media. After the 30-minute sampling, sodium arachidonate, 10 μg/ml, was added to the perfusate. The six specimens were explanted in duplicates at 24 hours (negative controls) and at 1 and 3 months. B, Production of 6-keto-PGF1α by normal control aortic segment of same six rabbits studied in A. Journal of Vascular Surgery 1988 7, DOI: ( / (88)90016-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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