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TDP1 knockdown increases the sensitivity of rhabdomyosarcoma cell lines to CPT treatment. TDP1 knockdown increases the sensitivity of rhabdomyosarcoma.

Published byLynn Benson Modified over 5 years ago

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Presentation on theme: "TDP1 knockdown increases the sensitivity of rhabdomyosarcoma cell lines to CPT treatment. TDP1 knockdown increases the sensitivity of rhabdomyosarcoma."— Presentation transcript:

1 TDP1 knockdown increases the sensitivity of rhabdomyosarcoma cell lines to CPT treatment.
TDP1 knockdown increases the sensitivity of rhabdomyosarcoma cell lines to CPT treatment. A, graphs showing the percent proliferation of rhabdomyosarcoma cells and control myoblasts over a 96-hour period during which the cells (i) received no CPT, (ii) were treated with 1 μmol/L CPT, or (iii) were treated with 1 μmol/L CPT after transient TDP1 knockdown (n = 4). B, graphs showing the results of an alkaline comet assay, which analyzes the number of DNA breaks (tail moment). The assay was performed after 2 hours of culture under the conditions stated above. Each dot represents a single cell/comet. A total of 100 cells were scored for each treatment. Error bars, mean ± SD; **, P < 0.01; ***, P < Hok Khim Fam et al. Mol Cancer Res 2013;11: ©2013 by American Association for Cancer Research

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