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Published byMaarit Ilona Saarnio Modified over 5 years ago
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Endometriosis may be associated with mitochondrial dysfunction in cumulus cells from subjects undergoing in vitro fertilization-intracytoplasmic sperm injection, as reflected by decreased adenosine triphosphate production Albert L. Hsu, M.D., Paige M. Townsend, M.Ph., Sergio Oehninger, M.D., Ph.D., Frank J. Castora, Ph.D. Fertility and Sterility Volume 103, Issue 2, Pages e1 (February 2015) DOI: /j.fertnstert Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 (A) Mitochondrial DNA-to-genomic DNA ratios in cumulus cells from subjects with endometriosis versus controls. Comparison of mitochondrial DNA:genomic DNA ratio for subjects with surgically confirmed endometriosis (n = 11) versus negative controls (n = 39), using nonparametric Kruskal-Wallis test with SAS version 9.3 (median, vs ; difference, +7.51%; P=.2294). (B) Adenosine triphosphate (ATP) levels in cumulus cells from subjects with endometriosis versus controls. Comparison of ATP/total DNA (in attomoles per nanogram) for subjects with surgically confirmed endometriosis (n = 11) versus negative controls (n = 39), using nonparametric Kruskal-Wallis test with SAS version 9.3 (median, vs attomoles/ng; difference, −64.98%; P=.0147). Fertility and Sterility , e1DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions
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