1. Risk factors and mechanisms of non-alcoholic steatohepatitis
Chantal A. Rivera 
Pathophysiology 
Volume 15, Issue 2, Pages (August 2008)
DOI: /j.pathophys
Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

2. Fig. 1
Overview of steatohepatitis risk factors and proposed mechanism. Over nutrition can lead to enhanced circulating fatty acids and possibly endotoxemia. Current data suggests that these agents stimulate intracellular signaling via interaction with TLR-4, resulting in the production of cytokines and chemokines, which stimulate inflammation, steatosis and ultimately lead to NASH. Several risk factors such as degree of adiposity, race and the presence of T2DM enhance the severity of NASH.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions