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Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis  Salman Siddiqui, MRCP, Amanda Sutcliffe, BSc (Hons), Aarti Shikotra,

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Presentation on theme: "Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis  Salman Siddiqui, MRCP, Amanda Sutcliffe, BSc (Hons), Aarti Shikotra,"— Presentation transcript:

1 Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis 
Salman Siddiqui, MRCP, Amanda Sutcliffe, BSc (Hons), Aarti Shikotra, BSc (Hons), Lucy Woodman, BSc (Hons), Camille Doe, BSc (Hons), MSc, Sue McKenna, RGN, Andrew Wardlaw, FRCP, PhD, Peter Bradding, DM, FRCP, Ian Pavord, DM, FRCP, Christopher Brightling, PhD, MRCP  Journal of Allergy and Clinical Immunology  Volume 120, Issue 4, Pages (October 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Immunohistochemistry vascular remodeling. Representative photomicrographs (×200) show bronchial biopsy sections stained with monoclonal antibody against PECAM-1/EN4. A, Control subject: relatively few vessels. B, Patient with mild intermittent asthma (GINA 1): increased vascularity. C, Subject with EB: multiple vessels in the subepithelium. D, Subject with refractory asthma: multiple vessels surrounding submucosal glands. RBM thickening is evident in subjects with asthma and EB. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 MMCs, cohort 1: control group; GINA 1-2 (intermittent to mild persistent asthma); GINA 3-5 (moderate to severe persistent asthma), including refractory asthma alone and nonrefractory; EB. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Induced sputum supernatant VEGF (pg/g), cohort 2. Sputum VEGF concentration in the control group; GINA 1-2 (intermittent to mild persistent asthma); GINA 3-5 (moderate to severe persistent asthma) including refractory asthma alone and nonrefractory; EB. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Vascular remodeling and airflow obstruction. In the subjects with asthma, there was an inverse association between the postbronchodilator FEV1 % predicted and the MCCs in cohort 1 (A) and sputum VEGF concentration in cohort 2 (B). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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