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A Multicenter Study of the Pharmacokinetics of Tacrolimus Ointment after First and Repeated Application to Children with Atopic Dermatitis  John Harper,

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Presentation on theme: "A Multicenter Study of the Pharmacokinetics of Tacrolimus Ointment after First and Repeated Application to Children with Atopic Dermatitis  John Harper,"— Presentation transcript:

1 A Multicenter Study of the Pharmacokinetics of Tacrolimus Ointment after First and Repeated Application to Children with Atopic Dermatitis  John Harper, Catherine Smith, Andris Rubins, Adrian Green, Karina Jackson, Sanita Zigure, John Bourke, Augustín Alomar, Paul Stevenson, Claire Foster, Nasrullah Undre  Journal of Investigative Dermatology  Volume 124, Issue 4, Pages (April 2005) DOI: /j X x Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Systemic exposure to tacrolimus. (a) Mean tacrolimus blood concentration–time profile (Day 1). (b) Mean tacrolimus blood concentration–time profile (Day 14). Journal of Investigative Dermatology  , DOI: ( /j X x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Systemic exposure to tacrolimus in pediatric atopic dermatitis patients compared with pediatric transplant patients. Mean area under the curve of tacrolimus in pediatric patients with moderate to severe atopic dermatitis treated with 0.1% tacrolimus ointment compared with pediatric liver transplant patients treated with tacrolimus systemically. Journal of Investigative Dermatology  , DOI: ( /j X x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions


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