1. Promoting and Accelerating New Evolving Nuclear Nano-Molecular PET/SPECT Imaging Technologies and Related Cyclotron Technologies in the Region
Sang Eun Kim, M.D., Ph.D.
Professor and Chairman
Department of Nuclear Medicine and Molecular Imaging
Seoul National University Bundang Hospital
Republic of Korea

2. Ageing Society Increasing life expectancy: World
Increasing life expectancy: Regions
World Population Ageing , United Nations

3. Ageing Society Percentage of population 60 years and older
Fertility Transition and Population Ageing in the Asian and Pacific Region, High level Meeting on the Regional Review of MIPAA, 2007

4. Alzheimer’s Disease Facts and Figures, 2007, Alzheimer’s Association
Annual Report 2007–2008,
Alzheimer’s Disease International

5. Prevalence of dementia (%) by WHO region and age group
The letters in brackets refer to the level of development of the region;
A= lowest mortality regions; E=highest mortality regions
Alzheimer’s Disease International fact sheet 2008,
Alzheimer’s Disease International

6. Estimated Global Cancer Burden
(Numbers of new cases of cancer per annum)
World Cancer Report 2008, WHO

7. Cancer incidence and mortality in the six WHO world areas
AFRO: Africa: EMRO: East Mediterranean; EURO: Europe; PAHO: PanAmerican;
SEARO: South-East Asia; WPRO: Western Pacific
SEARO
WPRO
World Cancer Report 2008, WHO

8. Estimated and projected numbers (millions) of cancer cases and deaths
World Cancer Report 2008, WHO

9. Nuclear Nano-Molecular PET/SPECT Imaging
See what is happening in living body at molecular levels
High sensitivity and target-specificity
Non-invasive and longitudinal monitoring
Quantitative
Cost-effective
New paradigm in medicine
Personalized medicine
Wide applicability
Useful for the detection and monitoring of neurodegenerative diseases (e.g., Parkinson’s disease, Alzheimer’s disease) and cancers

10. Nuclear Nano-Molecular PET/SPECT Imaging
Alzheimer’s disease
Healthy individual
Parkinson’s disease
Whole body PK
Target PK/PD
Advanced cancer

11. Technical Disparities in the Region
Developing Countries
Developed Countries
Technology
Instrumentation and Facility
Human Resources

12. Technical Disparities in the Region (Number per million population)
Institutions
Members
Gamma
cameras
Studies
PET
Cyclotron
(Number per million population)
(Number)
Japan
9.4 24
14762
350
150
Korea
2.5
3.3
4.7
11480
100 25
China
0.6
3.1
384
120 53
Philippines
0.2
0.3
551
2(3) 1
Thailand
0.7
0.4
328 4
Vietnam
113 3
Indonesia
0.07
0.09
0.14 88
Malaysia 2

13. Solving the Problems (Aims of this project)
Raise-up facilities and instrumentation
Enhance knowledge and technologies
Enrich human resources
Promote inter-regional/international cooperation
Increase support from international organizations
(RCA, IAEA, UNDP, etc.)

14. Specific objectives
Promote and accelerate new evolving nuclear nano-molecular PET/SPECT imaging technologies and related cyclotron technologies
Enhance neurochemistry imaging and molecular oncologic imaging technologies
Setup learning, training and hands-on practice courses
Establish a network of experts and facilities in the Region
Foster the capability of research and development

15. Strategies Train-the-Trainers On-site regional workshops
Hands-on practices
Interactive and customized training courses
Intra/inter-regional networking (including local and central offices)
In-depth evaluation and feedback

16. Transferable technologies involved
Pathophysiology relevant to nano-molecular imaging
Nano-molecular probe production from cyclotron
Image acquisition and reconstruction
Image analysis/interpretation and clinical applications
Neurochemistry imaging technologies
(e.g., Dopaminergic, serotonergic, cholinergic neurotransmitter system and amyloid plaque imaging)
Molecular oncologic imaging technologies
(e.g., Imaging of angiogenesis, membrane lipid synthesis, cell proliferation, tumor cell receptor, hypoxia, and other metabolic processes)

17. Detailed plans Jan - Mar Apr - Jun Jul - Sep Oct - Dec 2010
Expert meetings for training course protocol
Completion of protocols
Training courses #1,2 (4 wks each)
Training courses #3,4
(4 wks each)
2011
Training course #5 (4 wks)
Interim evaluation and report
On-site regional workshop #1
Hands-on practices #1
(short-term)
2012
Hands-on practices #2
On-site regional workshop #2
Intra/inter-regional networking (including local and central offices setup)
Final evaluation and report

18. Expected impact of the project
Contribute to the progress of clinical sciences
Augment the cyclotron application technologies and maximize the use of cyclotrons
Enrich basic and applied science capabilities in the Region

19. Strategies for the sustainability of the project
Training courses that are interactive and customized to needs of the region and the trainees
Establishment of expert networks
Interactive web-based systems
Persistent operation of local and central offices after the completion of the project

20. SNUBH Nuclear Nano-Molecular Imaging Center
Radiochemistry
Nano-Molecular
Imaging
Image Analysis/
Interpretation
3 PhDs
4 MS researchers
2 MDs
2 PhDs
5 MS researchers
3 MDs
1 PhD
4 MS researchers
Synthesis and development of
disease/target-specific nano-
molecules and molecular imaging
probes
Nano-molecular imaging QA
Animal models
Human volunteers
Imaging protocols and QA
Image analysis/quantification
and applications
Biological interpretation
Cyclotron Research Center
Nano-Molecular Imaging
Facilities
Image Lab

21. Major Facilities and Equipments
Cyclotron
Hot cells
Chemistry lab
PET/CT
Gas anesthesia
Dedicated animal holder
Translation storage
NanoSPECT
for animal imaging
NanoPET
for animal imaging
Dedicated animal
imaging chamber
Ventilated animal
cage racks
SPECT

22. Coordinator and active key members of the project lead country
Sang Eun Kim, M.D., Ph.D.
Professor and Chairman
Department of Nuclear Medicine and Molecular Imaging
Seoul National University Bundang Hospital
Republic of Korea
WW Lee,
MD, PhD
YK Kim,
MD. PhD
BC Lee,
PhD
YS Lee,
PhD
JJ Lee, MD
C Kim, MD
BS Moon,
PhD