1. Inteins Current Biology
Christopher W. Lennon, Marlene Belfort 
Current Biology 
Volume 27, Issue 6, Pages R204-R206 (March 2017)
DOI: /j.cub
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2. Figure 1 Global view of inteins.
(A) Mechanism of protein splicing: the four-step mechanism shown is for class 1 inteins with cysteines as the nucleophiles in both position 1 and +1. The N-extein is blue, intein is red, and C-extein is green, with other features listed. (B) Intein applications: the uses of inteins in biotechnology and as potential antimicrobials are listed. (C) Intein distribution in nature. Left: Inteins are found in all three domains of life, with the percentages shown being the fraction of sequenced genomes in each domain that contain an intein. Right: Percentage of inteins in bacteria and archaea found in replication, recombination, and repair (RRR) proteins. (D) Natural examples of conditional protein splicing: environmental cues that regulate protein splicing range from solution conditions, such as pH, redox, reactive oxygen and nitrogen species (ROS/RNS) and salt, through temperature and DNA damage.
Current Biology  , R204-R206DOI: ( /j.cub )
Copyright © 2017 Elsevier Ltd Terms and Conditions