1. Disrupted dynamic translational regulation of proneural factor Mash1.
Disrupted dynamic translational regulation of proneural factor Mash1. (A, B) Distribution and comparison of mean signal intensities over pixels of OP-puro signal in randomly selected fields (2–6 fields per sample) of wild-type (upper panels) and Chd5-deficient (lower panels) NSCs at all time points, as shown in representative images in Fig 4C. Data are represented as mean ± SD (n = 2). ns, no significance; ****<0.0001; Tukey’s multiple comparisons test. (C) Comparison of the Mash1+ populations between wild-type and Chd5-deficient NSCs at each time point. Data are represented as mean ± SD (n = 2). ns, no significance; *<0.05; ***<0.001; unpaired t test. (D) Temporal representation of the Mash1+ populations of wild-type (left panel) and Chd5-deficient (right panel) NSCs at the time points, as indicated in Fig 4F. Data are represented as mean ± SD (n = 2). ns, no significance; *<0.05; **<0.01; ****<0.0001; Tukey’s multiple comparisons test.
Dong-Woo Hwang et al. LSA 2018;1:e
© 2018 Hwang et al.