1. Intestinal differentiation is coupled with global rewiring of gene expression
Intestinal differentiation is coupled with global rewiring of gene expression Two row‐matched heatmaps showing the relative change in mRNA expression (left) and protein expression (right) of significantly changing proteins. Known markers of intestinal homeostasis are highlighted. Relative expression is shown as log2 fold change over the row mean.KEGG pathways that are significantly enriched (FDR < 0.01) in stem cell‐enriched organoids (blue) and differentiated organoids (red). Colors correspond to lines in (A) to show which gene clusters were used for enrichment analysis.Scatterplot showing the amount of protein copy numbers per mRNA molecule in CV and EN organoids. Proteins with significantly changing protein over mRNA ratios (FDR < 0.05 and fold change > 3 in both CV/EN and ENR/EN) are plotted in blue. Significantly changing known markers of intestinal homeostasis are highlighted.
Rik GH Lindeboom et al. Mol Syst Biol 2018;14:e8227
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