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Glucagon potentiates intestinal reperfusion injury

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1 Glucagon potentiates intestinal reperfusion injury
Elizabeth T. Clark, MD, Bruce L. Gewertz, MD  Journal of Vascular Surgery  Volume 11, Issue 2, Pages (February 1990) DOI: / (90)90270-K Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Experiments were performed in denervated isoperfused rat intestinal preparations. Journal of Vascular Surgery  , DOI: ( / (90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Histologic grading system. Epithelial morphology of individual intestinal sections was evaluated in a blinded manner by use of a modification of the Chui system. (Original magnification × 25.) Journal of Vascular Surgery  , DOI: ( / (90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Effect of glucagon before ischemia on intestinal blood flow (IBF) and oxygen extraction (VO2). Journal of Vascular Surgery  , DOI: ( / (90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 Histologic grades of experimental groups.
Journal of Vascular Surgery  , DOI: ( / (90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

6 Fig. 5 Oxygen extraction (VO2) and histologic grade as related to glucagon concentration and duration of ischemia. Journal of Vascular Surgery  , DOI: ( / (90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

7 Fig. 6 Concept of an “ischemic threshold” that relates mucosal injury to both blood flow and duration of flow disturbance. Increases in ischemic mucosal injury (e.g., grades 4 and 5) require longer periods of flow interruption and may not occur if perfusion is maintained above an arbitrary limit. Journal of Vascular Surgery  , DOI: ( / (90)90270-K) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions


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