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Defective dendritic morphology of V30M TTR sensory neurons.

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Presentation on theme: "Defective dendritic morphology of V30M TTR sensory neurons."— Presentation transcript:

1 Defective dendritic morphology of V30M TTR sensory neurons.
Defective dendritic morphology of V30M TTR sensory neurons. (A) Schematic of the morphology of an FLP sensory neuron. Dendrites: 1°: primary; 2°: secondary; 3°: tertiary; 4°: quaternary. (B) Representative confocal images of the head region of a day-1 adult animal showing the contour of FLP neurons as delineated by des-2p::Myristoyl::GFP with same orientation as in A. Insets show enlargements of quaternary dendritic branches. Inverted images shown. (C) Quantification of the FLP dendrites (mean ± SEM). n = 20 animals per strain. **P < 0.01, permutation t test. n.s., not significant. (D) Angles measured in E. (E) Histograms of the proportion of angular branches with a deviation greater than 0° in adult day-1 animals. *P < 0.025; two-sample Kolmogorov–Smirnov test comparing angles of V30M TTR and control/T119M TTR. See also SI Appendix, Fig. S7 and Tables S3 and S4. Kayalvizhi Madhivanan et al. PNAS 2018;115:33:E7710-E7719 ©2018 by National Academy of Sciences

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