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Melanoma Diagnosis by Confocal Microscopy: Promise and Pitfalls
Klaus J. Busam, Ashfaq A. Marghoob, Allan Halpern Journal of Investigative Dermatology Volume 125, Issue 3, Pages vii-ix (September 2005) DOI: /j X x Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Melanoma that was not recognized clinically or on confocal images. (A) Confocal image of a facial lesion thought to be clinically “negative” for melanoma shows a preserved honeycomb pattern of epidermal keratinocytes. (B) The corresponding histology reveals in situ melanoma. Journal of Investigative Dermatology , vii-ixDOI: ( /j X x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 2 Langerhans cells may simulate melanocytes on confocal images. (A) Confocal image of a bright dendritic cells within the spinous cell layer of the epidermis. (B) Conventional histology reveals a compound melanocytic nevus. (C) No pagetoid melanocytosis is seen on an immunostain for Melan-A. (D) Numerous Langerhans cells (dendritic cells immunopositive for CD1a) are present. Journal of Investigative Dermatology , vii-ixDOI: ( /j X x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions
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